Welcome to EHFPI!

EHFPI, a database of Essential Host Factors (EHFs) for Pathogenic Infections. This database focuses on the collection and functional analysis of a specialized class of host cellular genes identified from (genome-wide) RNA interface (RNAi) screens. Notably, the knockdown effect of these genes greatly influences the infection of a pathogen (e.g., inhibit or increase infection) but not the viability of the host cells, thus designated as essential host factors (EHFs) for pathogenic infections.

Currently, EHFPI contains detailed article, screen, and annotation information for a total of 4634 manually curated EHF genes, with phenotypes validated in Drosophila and Homo sapiens for 25 clinically important pathogen types. Besides the widest coverage, EHFPI also provides as many as six powerful analysis tools with graphic demonstrations, i.e., EHF-pathogen network analysis, EHF overlap analysis, gene enrichment analysis, pathogen interacting protein (PIP) analysis, drug target analysis, and genome-wide association study (GWAS) candidate gene analysis.

You can also submit EHF data to our website. Feel free to contact us if you have any question!

Workflow of genome-wide RNAi screen
EHF-pathogen Network Analysis
EHF Overlap Analysis
Distribution of EHFs for primary hits
Drug Target Analysis
PPI Network
jQuery Slider
Current Release

EHFPI2014_09, released September 30th, 2014.
Click here to view legacy release.

If you have any questions, please contact us!

EHFPI currently contains:
  • 6434 EHF genes
  • 14 viral species, 10 bacterial species, 1 fugal species